目前对为什么卵巢癌对免疫检查点抑制剂有抗性的理解
Anna Pawłowska1, Anna Rekowska2, Weronika Kuryło2
1Independent Laboratory of Cancer Diagnostics and Immunology, Department of Oncological Gynaecology and Gynaecology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
International journal of molecular sciences
|July 14, 2023
概括
卵巢癌 (OC) 经常在标准治疗后复发. 免疫检查点抑制剂 (ICI) 由于瘤抵抗机制,其有效性有限,因此需要进一步研究有效的免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 标准的卵巢癌 (OC) 治疗方法,如手术和化疗,长期表现不佳,约70%的晚期病例复发.
- 免疫检查点抑制剂 (ICI) 在OC患者中显示出有限的疗效 (10-15%的反应).
- 抗OC性归因于瘤异质性,瘤透性淋巴细胞 (TILs) 低,瘤微环境 (TME) 相互作用复杂,以及免疫检查点的微RNA调节.
研究的目的:
- 审查目前有关OC免疫疗法耐药性的因素的知识.
- 探索未来的发展方向,为OC患者开发有效的基于ICI的免疫疗法.
主要方法:
- 对影响OC治疗耐药性的因素的文献综述.
- 对OC耐药性的免疫学,分子和遗传机制的分析.
- 讨论ICI实施中的挑战,包括疾病进展评估.
主要成果:
- OC抗性是多因素的,涉及瘤特征和TME.
- 在OC中,ICI的有效性是有限的,特别是在低突变负担的瘤中.
- 从伪或超级进展区分真正的疾病进展是一个重大挑战.
结论:
- 了解OC耐药机制对于个性化免疫疗法选择至关重要.
- 需要对OC的免疫和分子环境进行进一步的研究,以提高ICI的有效性.
- 开发克服耐药性和准确评估进展的策略对于推进OC免疫疗法至关重要.
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