在患有炎症性肠病的门诊患者中,CRP与血液微生物群有关
Jie Xu1, Göran Molin1, Sanna Davidson2,3
1Department of Food Technology, Engineering and Nutrition, Lund University, 22100 Lund, Sweden.
International journal of molecular sciences
|July 14, 2023
概括
克罗恩病 (CD) 和性结肠炎 (UC) 患者的血液微生物群使用16S元基因组学绘制图谱. 发现了多样化的血液微生物群,其多样性与C反应性蛋白 (CRP) 水平有关.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 人类的循环系统传统上被认为是无菌的.
- 新出现的证据表明存在低密度的血液微生物群.
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),涉及复杂的宿主-微生物相互作用.
研究的目的:
- 用16S元基因组学来描述CD和UC的门诊患者的血液微生物群.
- 为了研究血液微生物组成和炎症标志物之间的关系.
- 为了确定IBD患者血液中存在的特定细菌种群.
主要方法:
- 来自CD和UC门诊患者的血液样本的16S元基因组测序.
- 微生物多样性 (α多样性) 和组成的分析.
- 包括非模板控制 (NTC) 来评估潜在的污染.
- 在CD和UC患者之间比较血液微生物群概况.
主要成果:
- 在CD和UC患者中检测到多样化的血液微生物群.
- 血液微生物群的α多样性与C反应性蛋白 (CRP) 水平正相关.
- 与口腔和结肠微生物群相比,血液微生物群呈现出高比例的蛋白质菌.
- 特定的细菌系 (Acinetobacter,Lactobacillus,Thermicanus,Paracoccus) 在患者血液中被发现,但在NTC中没有.
- 在血液样本中,Achromobacter是占主导地位的属,在NTC中含量较低.
- Micrococcaceae在CD患者中被丰富,但也存在于NTC中.
结论:
- 这项研究提供了IBD患者独特的血液传播微生物群的证据.
- 血液微生物群的多样性与系统性炎症 (CRP) 有关.
- 需要进一步的研究来探索血液微生物群在IBD中的诊断和治疗潜力.
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