ресвератрол通过激活自细胞来保护大鼠卵巢的化粒粉细胞免受H2O诱导的功能障碍
Minghui Cai1, Haijuan Sun1, Yujia Huang1
1Department of Physiology, Harbin Medical University, Harbin 150081, China.
International journal of molecular sciences
|July 14, 2023
概括
ресвератрол通过激活自,增强颗粒细胞功能和减少亡来防止白质细胞功能障碍. 这项研究揭示了白醇.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- ресвератрол表现出多种生物活动,包括潜在的自调节.
- 复星在保护质功能障碍方面的作用及其与自的相互作用仍然不清楚.
研究的目的:
- 为了研究resveratrol调节自的能力和保护对过氧化 (H2O2) 诱导的白质化粒素细胞功能障碍的 in vitro.
- 阐明白醇发挥其保护作用的机制.
主要方法:
- 在实验室中使用H2O2诱导的质化花粉素细胞功能障碍模型进行研究.
- 评估细胞活力,细胞亡和荷尔蒙分泌 (孕,雌激素).
- 通过测量与自相关的基因表达和自胞体/自胞体形成来分析自胞体的激活. 使用的自调节剂 (拉帕米,3-甲基亚丁,巴菲洛米A1).
主要成果:
- Ресвератрол显著提高了细胞活力,孕激素和雌激素分泌,并抑制了H2O2处理的细胞中的亡.
- ресвератрол通过上调与自相关的基因并增加自和自基因形成来激活自.
- 自调节器证实了白醇激活自的保护作用.
结论:
- 复星激活了自,以抵消H2O2诱导的氧化功能障碍在色化颗粒细胞中.
- 这种自的激活对于维持颗粒细胞分泌功能和预防亡至关重要.
- 这些发现突显了复星在通过自调节抵抗白色素功能障碍方面的潜在治疗作用.
更多相关视频
07:14A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
Published on: July 13, 2018
14.4K
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.2K
相关概念视频
01:24Peroxisomes
13.6K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
13.6K
01:27Autophagy
4.4K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.4K