老年男性的代谢综合征作为影响血清和骨中Mg,Ca和P之间的关系的一个因素
Aleksandra Rył1, Żaneta Ciosek1, Aleksandra Szylińska1
1Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54b, 71-210 Szczecin, Poland.
International journal of molecular sciences
|July 14, 2023
概括
代谢综合征 (MetS) 与荷尔蒙失衡和矿物质水平变化有关. 更高的可能会影响男性的骨代谢和性激素度.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 代谢综合征 (MetS) 是一组增加心血管风险的疾病.
- 荷尔蒙失衡和矿物质失调与MetS病理生理学有关.
- 矿物质 (Mg,Ca,P),荷尔蒙和MetS中的骨循环之间的相互作用需要进一步阐明.
研究的目的:
- 调查男性的MetS患病率,激素乱和血清/骨度之间的关系, (Mg), (Ca) 和 (P).
- 探索这些矿物质,性激素和有或没有MetS的男性骨周转率标志物之间的相关性.
主要方法:
- 研究包括152名男性,有或没有MetS.
- 测量了,雌激素,SHBG,DHEAS,胰岛素,骨素和骨周转标志物的血清水平.
- 在血清和骨组织中确定Mg,Ca和P度.
主要成果:
- 在MetS患者中,血清Ca与PINP和PTH相关;血清Mg与E2,PINP和PTH相关.
- 在非MetS患者中,血清Ca与SHBG和OC相关;骨 Ca与LAP和BMI相关.
- 骨Mg与非MetS患者的BMI和LAP正相关.
结论:
- 血清Mg的升高可能会影响骨组织代谢.
- 血清Mg水平升高与男性的性激素度和骨周转标记物发生变化有关.
- 这些发现突出了在患有MetS的男性代谢和骨健康方面的潜在作用.
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