抗β2-糖蛋白I/HLA-DR抗体和不良的产科结果
Kenji Tanimura1, Shigeru Saito2, Sayaka Tsuda2
1Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
International journal of molecular sciences
|July 14, 2023
概括
抗β2-糖蛋白I/HLA-DR抗体是导致重复妊娠损失 (RPL),胎儿生长限制 (FGR) 和妊娠高血压障碍 (HDP) 的重要危险因素. 这一发现突显了抗体在不良产科结果中的作用.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
背景情况:
- 抗β2糖蛋白I/HLA-DR (anti-β2GPI/HLA-DR) 抗体与抗脂综合征和重复妊娠损失 (RPL) 有关.
- 抗β2GPI/HLA-DR抗体与各种不良产科结果的特定关联需要进一步调查.
研究的目的:
- 预期评估抗β2GPI/HLA-DR抗体阳性与不良产科结果之间的关联,包括RPL,胎儿生长限制 (FGR),妊娠高血压障碍 (HDP) 和早产 (PD).
主要方法:
- 一项前性多中心横截面研究,涉及462名RPL女性,124名FGR女性,138名HDP女性,71名PD女性 (≤34GW),488名对照女性.
- 使用流细胞计分析测量血清抗β2GPI/HLA-DR抗体水平.
- 用多变量逻辑回归分析来计算不利结果的调整几率比率 (aOR).
主要成果:
- 抗β2GPI/HLA-DR抗体阳性率在RPL中为16.9%,在FGR中为15.3%,在HDP中为17.4%,在PD中为11.3% (≤34GWs),在对照组中为5.5%.
- 抗体阳性是RPL (aOR,3.3),FGR (aOR,2.7) 和HDP (aOR,2.7) 的一个显著的危险因素.
- 在抗体阳性和早产 (PD ≤ 34 GWs) 之间没有发现显著的关联.
结论:
- 抗β2GPI/HLA-DR抗体的阳性是导致重复流产,胎儿生长限制和妊娠高血压疾病的重要危险因素.
- 这项研究为抗β2GPI/HLA-DR抗体参与FGR和HDP的病理生理学提供了新的证据.
- 这些发现强调了在有不良产科结果史的妇女中查抗β2GPI/HLA-DR抗体的重要性.
关键词:
在HLAII类中,HLA是II类.抗脂综合征是一种抗脂综合征.自动抗体是一种自身抗体.胎儿生长限制 限制胎儿生长怀孕期间的高血压疾病.过早分娩 过早分娩经常发生的怀孕流产.β2-糖蛋白 I 是一种β2-糖蛋白.更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
867
08:07Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
10.1K
相关概念视频
01:19Rh Blood Group
1.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
02:45Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
01:22Development of Immunocompetence
357
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
357
01:10Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
01:31Adrenergic Antagonists: ɑ and β-Receptor Blockers
519
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
519