FTO 基因多态化及其在巨病中的作用
Aleksandra Jawiarczyk-Przybyłowska1, Justyna Kuliczkowska-Płaksej1, Katarzyna Kolačkov1
1Department and Clinic of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wrocław, Poland.
International journal of molecular sciences
|July 14, 2023
概括
脂肪质量和与肥胖相关的 (FTO) 基因多态性与心血管疾病 (CVD) 风险和IGF-1水平变化有关. 这些FTO变异会影响脂质代谢,这表明在这个人群中对心血管疾病风险的作用.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 心血管医学 心血管医学
背景情况:
- 心血管疾病 (CVD) 是壮病患者发病和死亡的主要原因.
- 脂肪质量和与肥胖相关的 (FTO) 基因多态性与肥胖和心血管疾病风险增加有关.
研究的目的:
- 调查FTO基因多态和脂质/葡萄糖代谢,以及IGF-1/GH水平与对照组相比,在壮病患者中之间的关联.
- 探索FTO基因变异在修改壮症中心血管疾病风险方面的潜在作用.
主要方法:
- 在104名壮病患者和64名对照患者中,对四种FTO基因多态 (rs1421085,rs9930506,rs9939609,rs1121980) 的基因定型.
- 与FTO基因型相关的脂质特征,葡萄糖代谢参数,IGF-1和GH水平的分析.
主要成果:
- 在整体壮症组中,携带FTO风险等位基因的携带者显示出较低的IGF-1度.
- 在得到良好控制的壮症中,特定FTO多态的同卵性载体具有较低的HDL胆固醇.
- 在治愈的壮症中,FTO rs9930506的同卵性载体表现出较高的总和LDL胆固醇水平.
- 在健康的对照组中没有观察到这些关联.
结论:
- FTO基因多态性与壮病患者的脂质代谢变化有关.
- FTO基因变异可能有助于增加心血管疾病风险.
- FTO基因多态性似乎影响IGF-1水平,可能影响其合成.
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