动脉样硬化免疫调节疗法:过去,现在和未来
Dalgisio Lecis1, Gianluca Massaro1, Daniela Benedetto1
1Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
International journal of molecular sciences
|July 14, 2023
概括
动脉样性心血管疾病是全球主要的健康问题,涉及慢性炎症. 本综述探讨了基于免疫的疗法,特别是疫苗接种,作为减少患者持续心血管风险的新策略.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 炎症生物学 炎症生物学
背景情况:
- 动脉样性心血管疾病是全球死亡的主要原因.
- 动脉壁的慢性炎症是这种疾病的一个关键特征.
- 目前的治疗方法使许多患者由于持续的炎症而存在显著的残留心血管风险.
研究的目的:
- 审查心血管疾病中基于免疫疗法的实验和临床证据.
- 专门评估用于降低心血管风险的疫苗接种策略.
- 为高残留心血管风险患者确定新的治疗途径.
主要方法:
- 关于动脉样硬化的免疫调节实验研究的文献综述.
- 对基于免疫的心血管干预的临床试验数据的分析.
- 专注于针对心血管疾病炎症途径的疫苗接种策略.
主要成果:
- 有证据表明,免疫系统调节可以控制动脉样硬化心血管疾病.
- 疫苗接种策略在临床前和临床环境中显示出降低心血管风险的前景.
- 炎症仍然是管理残留心血管风险的关键目标.
结论:
- 基于免疫的疗法,包括疫苗接种,是治疗动脉样硬化心血管疾病的一个有希望的前沿.
- 通过新的免疫策略向炎症对于改善高风险患者的治疗结果至关重要.
- 对心血管疾病接种疫苗的进一步研究有可能产生显著的临床影响.
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