带有素的细菌外膜囊泡通过以协同的方式调节与瘤相关的巨细胞再极化来抑制瘤的发展
Shoujin Jiang1, Wei Fu1, Sijia Wang1
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
International journal of molecular sciences
|July 14, 2023
概括
携带perhexiline的外膜囊泡 (OMVs) 将瘤相关巨细胞 (TAMs) 从M2型转变为M1型表型. 这种OMV@Perhx策略通过促进亡和抑制瘤细胞迁移来增强抗瘤活性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 与瘤相关的巨细胞 (TAMs) 对瘤进展和转移至关重要.
- 主要与M2相似的TAMs可以被重新编程成与M1相似的抗瘤表型.
- 外膜囊泡 (OMVs) 具有作为药物载体和免疫调节剂的潜力.
研究的目的:
- 为了研究来自大肠杆菌的OMVs的有效性,Nissle 1917装载有 perhexiline (OMV@Perhx) 在TAMs的再极化中.
- 评估OMV@Perhx介导的TAM再极化对抗瘤的影响.
主要方法:
- 用OMV@Perhx治疗巨细胞以诱导TAM再极化.
- 评估了复极化巨细胞对瘤细胞亡,入侵和迁移的影响.
- 分析了组合OMVs和peremxiline的协同抗瘤作用.
主要成果:
- OMV@Perhx有效地将类似M2的TAM重聚为类似M1的表型.
- 重极化的巨细胞显著促进了瘤细胞的亡.
- 瘤细胞的入侵和迁移被复极化巨细胞抑制.
结论:
- OMVs增强了fermixiline的疗效,作为一种新药载体和免疫调节剂.
- 联合OMV和peremxiline治疗表现出强大的协同作用的抗瘤作用.
- 这种方法有望通过利用OMV和化学药物开发新的癌症疗法.
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