改变牛皮的护理:益生菌和益生菌作为新的治疗方法
Mihaela Cristina Buhaș1, Rareș Candrea2, Laura Ioana Gavrilaș3
1Department of Dermatology, Toxicology and Clinical Pharmacology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400423 Cluj-Napoca, Romania.
这项研究表明,益生菌和益生菌通过积极改变肠道微生物群来改善牛皮症状和皮肤健康. 在接受局部治疗的患者中,补充剂增强了疾病活性测量和减少了炎症.
科学领域:
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,与肠道微生物群失调有关.
- 益生菌和益生菌在治疗牛皮症状方面表现有前途.
- 了解这些干预措施对代谢,免疫和肠道变化的影响至关重要.
研究的目的:
- 为了评估特定益生菌和益生菌组合在牛皮患者的疗效.
- 评估疾病活动,炎症标志物和肠道微生物群组成的变化.
- 探索与干预相关的潜在代谢和免疫学转变.
主要方法:
- 一个为期12周的开放标签,单中心临床试验,涉及63名牛皮患者.
- 干预组接受了局部治疗加上益生菌和益生菌;对照组仅接受了局部治疗.
- 评估的牛皮面积和严重性指数 (PASI),皮肤病生活质量指数 (DLQI),炎症标志物,皮肤厚度和肠道微生物群.
主要成果:
- 接受补充剂的患者在疾病活性 (PASI,DLQI) 中显著改善,炎症标志物减少,皮肤厚度降低.
- 在一小部分患者的肠道微生物群分析显示,12周后,肠道微生物群向抗炎性特征转变为有利.
- 尽管基线差异很大,干预组与对照组相比,表现更好.
结论:
- 益生菌和益生菌补充剂,以及局部治疗,在治疗牛皮方面是有效的.
- 该干预措施积极调节肠道微生物群,有助于抗炎状态.
- 需要进一步的研究来阐明精确的机制和长期影响.
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