单个纳米粒子的尺寸不确定性通过单个粒子诱导合等离子体质谱法测量
Shuji Yamashita1, Shin-Ichi Miyashita1, Takafumi Hirata2
1National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 3-9, 1-1-1 Umezono, Tsukuba 305-8563, Ibaraki, Japan.
Nanomaterials (Basel, Switzerland)
|July 14, 2023
概括
评估了使用单颗粒感应合等离子体质谱法 (spICP-MS) 确定纳米粒子大小的不确定性. 使用高度离子标准溶液,与粒子大小标准相比,大小测量精度大大提高.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 单粒子感应合等离子体质谱法 (spICP-MS) 是个别纳米粒子 (NP) 尺寸分析的一个关键技术.
- 准确的尺寸确定对于理解NP行为和应用至关重要.
- 现有的校准方法在实现高精度方面存在挑战.
研究的目的:
- 评估和比较与spICP-MS尺寸测量的两个不同的校准方法相关的不确定性.
- 确定每种校准方法中导致不确定性的因素.
- 为提高NP大小确定精度提供建议.
主要方法:
- 使用spICP-MS.研究了50nm银NP的尺寸分析.
- 评估了两个校准方法: (i) 粒子大小标准和 (ii) 离子标准解决方案.
- 在不同的条件下,每个方法的量化相对不确定性.
主要成果:
- 粒子大小标准方法给出了相对不确定性,为50纳米银NP的9.9%至15.0%.
- 离子标准溶液方法显示相对不确定性为18.5% (1 ng/g),7.6% (10 ng/g) 和4.7% (100 ng/g).
- 离子标准溶液的较高度导致不确定性明显降低.
结论:
- 离子标准溶液方法,特别是高度,为spICP-MS的NP尺寸确定提供了更高的精度.
- 影响不确定性的因素包括信号强度变化,标准分布和校准曲线斜率.
- 建议使用高度离子标准解决方案,以提高spICP-MS纳米粒子尺寸的精度.
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