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Updated: Jun 17, 2026

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"纳米粒子的生物和毒理学研究"特别号的编辑

Olivier Joubert1

  • 1Institut Jean Lamour, CNRS 7198, University of Lorraine, 54015 Nancy, France.

Nanomaterials (Basel, Switzerland)
|July 14, 2023
PubMed
概括

纳米粒子表现出独特的尺寸依赖性质,引发了大量的研究兴趣. 它们的独特特征对于各种科学领域的进步至关重要.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...