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通过乙烯转移进行硫胺辅助的C-H激活和取消:获取未被替代的西亚

Koneti Kondalarao¹, Somratan Sau¹, Akhila K Sahoo¹

¹School of Chemistry, University of Hyderabad, Hyderabad 500046, India.

Molecules (Basel, Switzerland)

|July 14, 2023

概括

研究人员通过Rh(III) 催化C-H激活和乙烯碳酸盐合成了1,2-二. 这种方法有效地产生光学纯的索衍生物,展示了一种新的合成途径.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
药用化学医学化学

背景情况:

1,2-西是重要的异环基架,具有多样化的生物活动.
对于1,2-二亚的高效和选择性合成方法非常受欢迎.

研究的目的:

开发一种新的,氧化还原中性合成途径,以获得非替代的1,2-二.
为了探索Rh(III) 催化C-H激活和 [4+2] 取消用于构建索衍生物的实用性.
为了实现光学纯净的1,2-二亚的合成.

主要方法:

氧中性Rh(III) 催化C-H激活和 [4+2] 取消反应.
作为反应伙伴,利用了S-aryl sulfoximines和乙烯碳酸乙烯.
采用一个N受保护的氨基酸联体来增强反应速度.

主要成果:

成功合成了一系列多样化的1,2-西衍生物,产量中等至高.
乙烯基碳酸作为氧化乙烯替代物和乙烯基转移剂.
在合成产品中证明了高反体纯度的潜力.

结论:

开发了一种高效的Rh (III) 催化协议,用于1,2-西亚合成.
突出了维尼烯碳酸盐在氧化还原中性无效反应中的多功能性.
建立了一种途径,以获取基丰富的1,2-二.

关键词:

在CH激活过程中.氧化还原中性还原中性.硫胺是一种硫胺.维尼烯转移转移的维尼烯.

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