用蛋白素 (HEWL) 对宿主免疫的药理调节-一篇评论
Alberta Bergamo1, Gianni Sava1,2
1Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Molecules (Basel, Switzerland)
|July 14, 2023
概括
蛋白中的酶 (HEWL) 通过口服通过肠关联淋巴组织 (GALT) 刺激免疫系统. HEWL在治疗免疫功能受损的疾病和提高化疗疗效率方面显示出潜力,并且没有副作用.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 100年前发现的酶在各种领域和治疗应用中至关重要.
- 本综述侧重于蛋白溶酶 (HEWL) 和其在口服后的免疫调节作用.
- 肠关联淋巴组织 (GALT) 在源自肠道的免疫激活中起着中心作用.
研究的目的:
- 审查口服蛋白溶酶 (HEWL) 与免疫系统之间的相互作用.
- 调查HEWL在免疫受损状态中的潜在治疗作用及其对化疗的影响.
- 评估HEWL作为免疫调节剂的安全性和有效性.
主要方法:
- 对HEWL与免疫系统相互作用的实验数据的审查.
- 分析涉及GALT和肠道淋巴细胞的免疫刺激途径.
- 检查HEWL对免疫抑郁和化疗结果的影响.
主要成果:
- 口服HEWL通过GALT激活免疫系统,独立于其酶活性.
- 霍尔证明了扭转瘤或免疫抑制剂引起的免疫抑郁的潜力.
- 在初步研究中,HEWL的使用改善了化疗成功率.
结论:
- HEWL是一种有前途的口服免疫调节剂,通过GALT刺激免疫系统.
- HEWL对涉及免疫缺陷或需要免疫增强的疾病具有治疗潜力.
- 易于口服和缺乏副作用支持HEWL在治疗各种病理方面的作用.
相关概念视频
Humoral Immune Responses
73.1K
Overview
73.1K
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Cell-mediated Immune Responses
69.0K
Overview
69.0K
Antimicrobial Proteins
1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K
Microorganisms in Medicine and Therapeutics
62
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
62
Cytotoxic T Cells-mediated Immune Response
985
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
985


