氧化纳米颗粒通过加强再氧化系统来缓解酸诱导的毒性
Ibrahim M Alhazza1, Iftekhar Hassan1, Hossam Ebaid1
1Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules (Basel, Switzerland)
|July 14, 2023
概括
绿色合成的氧化纳米颗粒 (ZnO NPs) 显示出对大鼠中酸 (PB) 诱导的毒性有显著的治疗潜力. 这项研究强调了ZnO NP.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 纳米技术纳米技术
背景情况:
- 酸 (PB) 是已知的致癌物和食品添加剂,通过暴露而构成风险.
- 暴露于PB可以导致显著的毒性,特别是影响功能和氧化还原状态.
- 开发有效的对抗PB诱导的毒性对公共卫生和工业安全至关重要.
研究的目的:
- 研究绿色合成的氧化纳米颗粒 (ZnO NPs) 对PB诱导的毒性的改善作用.
- 评估ZnONP对功能标记物和PB暴露的老鼠的氧化还原状态的影响.
- 评估ZnO NPs在缓解PB诱导的细胞和DNA损伤方面的治疗潜力.
主要方法:
- 瑞士白色老鼠暴露于PB,并用不同度的氧化 (ZnO) 和ZnONP进行治疗.
- 血液和脏样本被分析为功能标志物和氧化还原状态.
- 组织和核DNA完整性被评估以评估细胞损伤.
主要成果:
- 在大鼠中,PB暴露显著改变了功能标志物和扰乱了氧化还原状态.
- 单独ZnO和ZnONP显示出中度毒性影响.
- 与单独使用PB (组II) 相比,同时使用PB和ZnONP (组VI) 显著改善了PB诱导的毒性.
结论:
- 绿色合成的 ZnO NPs 在体内对PB诱导的毒性具有显著的治疗潜力.
- ZnO NPs可以减轻PB暴露引起的生化和DNA损伤.
- 这些发现支持在针对毒性或提高PB工业用途安全性的药物应用中使用ZnO NP.
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