抗氧化活性,抗癌活性,物理化学特性和酸/酸聚合物的急性毒性
Nguyen Xuan Hoan1, Le Thi Hong Anh2, Hoang Thai Ha2
1Faculty of Biology and Environment, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh 70000, Vietnam.
Molecules (Basel, Switzerland)
|July 14, 2023
概括
酸/酸是一种来自海藻和玉米的生物聚合物,具有抗氧化和α-葡萄糖酶抑制的特性. 它显示出药品和功能性食品的潜力,在小鼠中具有低急性毒性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物化学 生物化学
背景情况:
- 酸盐和酸盐是具有显著生物活性的天然聚合物.
- 酸盐和素的组合创造了一种具有潜在应用的新型生物材料.
- 了解酸盐/木质素的特性对于其发展至关重要.
研究的目的:
- 为了评估酸盐/酸的抗氧化活性.
- 为了评估酸盐/酸丁对各种细胞系的抗癌潜力.
- 描述酸盐/酸的物理化学特性和急性毒性.
主要方法:
- 抗氧化剂测定包括总抗氧化活性,降低功率,DPPH清除和α-葡萄糖酶抑制.
- 对Hep G2,MCF-7,NCI H460细胞系和纤维细胞的抗癌活性评估.
- 使用FTIR,DSC,SEM-EDS,XRD,XRF和1H-NMR进行物理化学表征.
- 对瑞士白色老鼠的急性毒性研究.
主要成果:
- 酸/酸显示出显著的总抗氧化剂和降低功率活动,具有显著的α-葡萄糖酶抑制,但没有DPPH自由基清除活性.
- 该物质在测试细胞系中没有显著的抗癌活性.
- 物理化学分析显示了热稳定性,球形形态以及C,O,Na和S等元素的存在.
- 在急性毒性研究中,小鼠的LD0为3.91g/kg,LD100为9.77g/kg.
结论:
- 酸/酸具有宝贵的抗氧化特性,特别是α-葡萄糖酶抑制,这表明糖尿病管理的潜力.
- 这种生物材料热稳定,呈现出正规的球形结构.
- 低急性毒性表明潜在应用的安全性概况有利.
- 酸/酸对制药材料,功能性食品和治疗应用具有前景.
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