桑宁可以与虫有直接相互作用:通过异热定位热量计的调查
Mimosa Sillanpää1, Marica T Engström1, Petri Tähtinen1
1Department of Chemistry, University of Turku, FI-20014 Turku, Finland.
Molecules (Basel, Switzerland)
|July 14, 2023
概括
植物色素显示与一种杀虫剂的提亚本达直接相互作用. 它们的联合使用可能会影响药物的疗效,结构特征会影响相互作用强度.
科学领域:
- 兽医药理学 兽医药理学
- 自然产品化学 自然产品化学
- 寄生虫学的寄生虫学
背景情况:
- 植物色素具有抗虫和抗寄生素的特性,使其成为打击抗虫耐药性的焦点.
- 作为商业杀虫剂的补充剂,研究阳是一种有希望的策略,尽管相互作用尚未完全理解.
- 有限的研究存在于素-虫相互作用,报告有协同作用和对抗作用影响药物疗效.
研究的目的:
- 为了研究水解素 (HTs) 和西米达抗甲虫剂 thiabendazole (TBZ) 之间的直接相互作用.
- 了解HT的结构特征如何影响它们与TBZ的相互作用.
- 评估这些相互作用对商业杀虫剂疗效的潜在影响.
主要方法:
- 为研究选择一系列可水解素 (HTs).
- 使用异热定位热量计 (ITC) 评估选择的HTs和 thiabendazole (TBZ) 之间的直接相互作用.
- 对HT的结构特征进行分析,这些特征有助于观察到的相互作用.
主要成果:
- 水解 (HTs) 与 thiabendazole (TBZ) 呈现直接的外热相互作用.
- HT-TBZ相互作用的强度与 tannin 结构中自由的 galloyl 群的数量正相关.
- 增强HT的分子灵活性也增强了它们与TBZ的相互作用.
结论:
- 可水解素 (HTs) 可以直接与本齐米达抗甲虫剂 thiabendazole (TBZ) 相互作用.
- HTs的结构特征,特别是基群丰度和分子灵活性,显著调节这些相互作用.
- 结果提供了关于植物衍生化合物和商业虫剂之间的复杂相互作用的见解,这与管理抗虫剂耐药性有关.
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