果叶提取物 (Zynamite®) 与奎尔素结合,在人类骨肌肉中具有运动模仿性质
Miriam Martinez-Canton1, Victor Galvan-Alvarez1, Eduardo Garcia-Gonzalez1
1Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.
Nutrients
|July 14, 2023
概括
辛纳米特PX®,一种果叶提取物和氨酸补充剂,改变了静止状态的肌肉信号通路. 它还会抑制运动引起的应激反应,类似于训练有素的肌肉.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 营养科学 营养科学
背景情况:
- 众所周知,Zynamite PX® (果叶提取物 + 氨酸) 可以提高运动表现.
- 其 ergogenic 作用的潜在分子机制在很大程度上是未知的.
研究的目的:
- 为了研究Zynamite PX®补充剂后骨肌中的分子信号适应.
- 将这些适应与补充和对照组的运动诱导反应进行比较.
主要方法:
- 25名志愿者被分为对照组和Zynamite PX®补充剂组.
- 补充包括140毫克Zynamite® + 140毫克奎尔塞丁每8小时两天.
- 肌肉活检是在休息时收集的,在逐步炼到疲后,并在Wingate冲刺测试后进行.
主要成果:
- 与对照组相比,Zynamite PX®组表现出Thr287-CaMKIIδD和Ser9-GSK3β的基底蛋白表达增加.
- 在Zynamite PX®组中观察到基底NRF2和Ser40-NRF2增加的趋势.
- 在对照组中观察到的NRF2,catalase,Glutathione Reductase和Thr287-CaMKIIδD的运动诱导上调,在Zynamite PX®组中没有.
结论:
- 齐纳米特PX®诱导休息骨肌的信号变化,模仿运动训练适应.
- 补充剂部分取消了运动诱导的压力激酶反应,类似于训练有素个体所见的适应.
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