氨基酸的饮食操纵用于癌症治疗
Julio José Jiménez-Alonso1, Miguel López-Lázaro1
1Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain.
Nutrients
|July 14, 2023
概括
操纵饮食中的氨基酸 (AAs) 可以使癌细胞饿死. 在人工饮食中限制特定的AAs显示出抑制癌症扩散和改善转移模型中的存活率的承诺.
科学领域:
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
- 营养科学 营养科学
背景情况:
- 癌细胞需要所有20种蛋白质生成氨基酸 (AAs) 进行增殖和生存.
- 癌细胞具有遗传和代谢变化,这些变化会影响它们在充满挑战的环境中获得足够的AAs的能力.
- 正常的饮食通常在恒定的水平上提供AA,掩盖这些癌症特异性的脆弱性.
研究的目的:
- 对操纵氨基酸饮食的抗瘤作用的体内研究进行审查.
- 评估单个和组合氨基酸限制或补充剂的影响.
- 介绍关于用于癌症治疗的同时氨基酸操纵的最新发现.
主要方法:
- 评估饮食氨基酸操纵的体内研究的综述.
- 分析涉及单个和组合氨基酸限制/补充的研究.
- 包括最近关于多氨基酸饮食干预措施的实验数据.
主要成果:
- 对特定氨基酸 (AAs) 的饮食操纵可以选择性地准癌细胞的增殖.
- 在各种体内模型中,限制或补充个别的AAs已经显示出抗瘤活性.
- 同时操纵多个AAs在患有转移性癌症的小鼠中显示出显著的生存改善.
结论:
- 改变饮食中的氨基酸成分是对抗癌症的潜在治疗策略.
- 通过饮食准癌症的特定AA依赖,可以克服代谢脆弱性.
- 多氨基酸饮食干预措施需要进一步研究癌症治疗,特别是转移性疾病.
关键词:
它具有抗癌活性,具有抗癌活性.在阿根廷,阿根廷人.人工饮食的人工饮食.阿斯巴拉基因 (asparagine) 是一种癌症的代谢 癌症的代谢半氨酸 (cysteine) 是一种氨酸.基本氨基酸是必需的氨基酸.谷氨胺是一种在活体中,活体中氨酸 (leucine) 是一种蛋白质.甲氨酸的使用方法鼠标 鼠标 鼠标 鼠标非必不可少的氨基酸.限制的限制限制的限制.血清蛋白质是什么 血清蛋白质更多相关视频
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