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在早产新生儿中早期的能量摄入量和氨基酸概况:一项准实验性研究

Giovanni Boscarino¹, Claudia Carducci², Maria Giulia Conti¹

¹Department of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

|July 14, 2023

概括

增强的亲肠道营养 (PN) 能量摄入量没有改变早产新生儿的血液氨基酸 (AA) 水平. 研究人员建议小心使用高能量的PN在生命的第一个星期,因为潜在的副作用.

科学领域:

新生儿科学新生儿科学
营养科学营养科学
生物化学生物化学

背景情况:

亲肠道营养 (PN) 对早产新生儿至关重要.
通过PN增加蛋白质摄入量可以改善新生儿的平衡.
能量摄入对PN中的氨基酸利用的影响还不清楚.

研究的目的:

研究PN中不同能量摄入对早产婴儿血中氨基酸 (AA) 水平和形状的影响.
为了确定通过PN增强的能量传递是否会影响AA利用.
为了比较接受标准与能量增强PN的早产婴儿之间的AA概况.

主要方法:

采用了一种准实验性的研究设计.
预产期非常低出生体重的新生儿被分为两个组:能量增强PN (A组) 和标准能量PN (B组).
血中氨基酸水平在两个时间点测量 (T0: 3-7天;T1: 15天) 并在队列之间进行比较,并给予相似的蛋白质量.

主要成果:

在T0时,两组之间没有观察到血液中总必需和非必需氨基酸度的显著差异.
在T1时,B队列 (标准能量PN) 与A队列 (增强能量PN) 相比,呈现出较高度的白氨酸,阳光白氨酸和氨酸,以及较低的氨酸.
多变量分析没有证实这些特定的氨基酸度差异,这表明它们可能没有临床意义.

结论:

在生命的第一个星期通过腹腔营养增加的能量摄入量并没有显著改变早产婴儿的氨基酸水平或蛋白质.
该研究建议在通过PN给早产新生儿高能量剂量时谨慎使用,因为潜在的风险和对AA利用缺乏明确的益处.
需要进一步的研究,以充分阐明新生儿亲肠营养中最佳的能量和蛋白质策略.

关键词:

这种异质素是isoleucine 氨酸 (leucine) 是一种蛋白质.这是新生儿新生儿.营养营养营养营养营养摄入量营养摄入量亲肠营养亲肠营养血氨基酸是血氨基酸的一种.普罗林是什么意思普罗林是什么意思蛋白质摄入量蛋白质摄入量泰洛辛 (tyrosine) 是一种蛋白质.非常低的出生体重.

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