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皮质液胆酸和结肠直肠高级腺瘤之间的关联
Hung N Luu1,2, Chi Thi-Du Tran3,4,5, Renwei Wang1
1UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Nutrients
|July 14, 2023
概括
改变的胆汁胆酸,特别是较高的氧化胆酸 (HCA) 种和较低的氧化胆酸 (UDCA),与结直肠晚期腺瘤有关. 这些发现表明,早期检测结直肠癌的潜在生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 生物化学 生物化学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 查需要可靠的生物标志物来进行早期检测.
- 先进的腺瘤是CRC的关键前体,需要识别相关的分子变化.
- 与晚期结直肠腺瘤相关的汁胆汁酸变化尚未被探索.
研究的目的:
- 为了调查叶汁胆酸概况与结直肠晚期腺瘤存在之间的关联.
- 为了识别可能作为生物标志物用于先进腺瘤检测的特定胆汁酸.
主要方法:
- 使用超高性能液体染色学-三重四极质谱学量化叶汁中综合胆酸面板的量化.
- 对46名接受结肠镜检查的受试者 (14名患有晚期腺瘤,32名对照) 的分析.
- 统计分析 (ANCOVA) 用于比较各组之间的胆酸度,调整共变量.
主要成果:
- 与对照组相比,在晚期腺瘤患者中观察到显著更高的度的氧化酸 (HCA) 物种 (p=0.001).
- 在病例与对照中发现,ursodeoxycholic acid (UDCA) 的相对丰度显著降低 (p=0.046).
- 对于总或特定的初级胆汁酸 (胆汁酸,胆汁酸) 或主要的二次胆汁酸,没有发现显著差异.
结论:
- 胆汁胆酸成分在患有结直肠晚期腺瘤的个体中发生变化.
- 高水平的HCA物种可能会导致晚期腺瘤的发展.
- 肠道微生物群减少切诺二氧化醇酸 (CDCA) 转化为UDCA可能会增加风险,突出了CRC早期检测的潜在生物标志物.
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