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在50岁以上的老年人中,肺功能与骨髓缩性肥胖症的关联
Han-Sol Lim1, Dong-Kun Kim1, Hyun-Il Gil2
1Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.
Nutrients
|July 14, 2023
概括
骨髓缩性肥胖 (OSO) 是一种结合骨,肌肉和脂肪问题的疾病,与50岁以上成年人肺功能减弱有关. 更多异常的身体组成与较差的肺功能相关,特别是限制性螺旋测量模式.
科学领域:
- 老年学是一门学科.
- 肺部病理学 肺部病理学
- 代谢健康 代谢健康
背景情况:
- 骨髓疏松性肥胖症 (OSO) 是一种复杂的疾病,其特点是同时存在骨质疏松症/骨质疏松症,骨髓疏松症和肥胖症.
- 这种多因素状况显著影响整体健康,特别是在老年人群中.
- 了解OSO和其他生理系统 (如呼吸系统) 之间的相互作用,对于全面的健康管理至关重要.
研究的目的:
- 在50岁及以上的成年人中调查肺功能与骨髓缩性肥胖 (OSO) 之间的关联.
- 为了确定异常的身体成分 (骨质疏松症/骨质疏松症,骨髓疏松症,肥胖症) 的数量是否与特定的螺旋测量模式相关.
- 确定OSO作为老年人肺功能下降的独立风险因素.
主要方法:
- 从26,343名参与者 (年龄≥50岁) 的数据分析,根据异常体质组成数量 (0,1+,2+,3+OSO) 分类.
- 使用强迫生命能力 (FVC) %,1秒内强迫呼气体积 (FEV1) %和FEV1/FVC%来评估肺功能.
- 进行了多变量分析,以调整潜在的混因素,并确定独立的关联.
主要成果:
- 肺功能参数 (FVC%,FEV1%,FEV1/FVC%) 随着异常体质组成数量的增加而显著下降 (p < 0.0001).
- 限制性螺旋测量模式 (RSP) 的患病率与更高数量的异常体质参数 (p < 0.001) 有积极关联,而阻断性螺旋测量模式 (OSP) 显示没有关联.
- 与对照组相比,RSP的调整赔率比率随着异常组合数量的增加而增加:1.36 (1+),1.47 (2+) 和1.64 (3+OSO) (趋势p<0.001).
结论:
- 在50岁以上的成年人中,多种异常的身体组成,特别是骨髓缩性肥胖,独立地与肺功能不佳有关,特别是限制性螺旋计模式.
- 骨质疏松症/骨质疏松症,骨质疏松症和肥胖症的同时存在可能会使个体易患肺功能恶化.
- 在老年人群中,OSO是呼吸系统衰竭的重要危险因素,这凸显了综合健康评估的必要性.
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