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Bovine Ovarian Cortex Tissue Culture
Published on: January 14, 2021
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饮食中的蛋白质调节女性雌性循环,部分是通过纤维细胞生长因子21来调节
Yaxue Cao1, Min Yang1,2, Jie Song1
1Key Laboratory for Animal Disease Resistant Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Nutrients
|July 14, 2023
概括
严重的饮食蛋白质限制会破坏雌性周期和卵巢发育. 肝纤维细胞生长因子21 (FGF21) 和下丘脑Kiss-1部分参与了这个过程.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 营养科学 营养科学
背景情况:
- 纤维细胞生长因子21 (FGF21) 是一种由肝脏衍生的激素,信号饮食蛋白质摄入量.
- 在不同的食蛋白水平下,FGF21在调节雌性循环中的作用尚未完全理解.
研究的目的:
- 调查FGF21和下丘脑变化的作用,以饮食蛋白调节雌性循环.
- 确定不同饮食蛋白质水平对雌性大鼠生殖参数的影响.
主要方法:
- 鼠被食不同蛋白质含量 (4%至23%) 的饮食.
- 使用肝脏特异性FGF21淘汰和野生型小鼠来评估肝脏FGF21的作用.
- 评估了雌激素周期性,体重,子宫和卵巢毛囊发育.
主要成果:
- 饮食中蛋白质限制低于8%对雌激素循环,体重和卵巢发育产生了负面影响.
- 严重的限制 (4%蛋白质) 降低了在下丘脑中的Kiss-1表达.
- 增加的FGF21水平与减少的饮食蛋白质相关,FGF21缺乏延迟了循环破坏.
结论:
- 严重的饮食蛋白质限制会阻止雌激素循环和卵巢卵泡的发育.
- 肝脏FGF21和下丘脑Kiss-1在调解这些影响方面发挥了部分作用.
- 通过增加饮食中的蛋白质含量,可以恢复生殖功能.
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