抗脂质活性的Rhaponticum carthamoides及其二次代谢物
Velislava Todorova1, Martina S Savova2, Stanislava Ivanova1
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Nutrients
|July 14, 2023
概括
拉芬蒂 (Rhaponticum carthamoides) 提取物 (RCE) 和20-hydroxyecdysone (20E) 减少脂肪的积累,并促进人类细胞中的脂肪分解. 土耳其 (TU) 减少脂肪的积累,但不会影响脂肪的分解.
科学领域:
- 植物化学 植物化学
- 代谢科学 代谢科学
- 细胞生物学 细胞生物学
背景情况:
- 这种植物是Rhaponticum carthamoides (Willd.) 伊尔金. 伊尔金. 这就是伊尔金. (RCE) 被称为适应原体,可能会影响脂质代谢.
- 植物类固醇是RCE中的关键二次代谢产物.
- 了解RCE对脂肪生成和脂肪溶解的影响对于代谢健康至关重要.
研究的目的:
- 开发和验证一种高性能薄层染色学 (HPTLC) 方法,用于RCE植物性固体形.
- 调查RCE及其主要植物固醇对人体细胞脂肪生成和脂肪解的作用.
- 为了比较20-hydroxyecdysone (20E),ponasterone A (PA) 和turkesterone (TU) 的活性.
主要方法:
- 开发和验证一个敏感的HPTLC方法用于RCE分析.
- 利用人类的辛普森-戈拉比-贝梅尔综合征细胞来评估抗脂原和脂解效应.
- 通过染色和测量释放的甘油和自由脂肪酸的量化脂质积累.
主要成果:
- 在RCE中,HPTLC证实了20E,PA和TU的存在.
- RCE,20E和TU显著降低了脂质积累 (抗增脂效应).
- RCE和20E刺激了基底脂解;PA和TU对脂解没有显著影响.
结论:
- RCE和20E对脂质生成和脂质分解都表现出双重作用.
- TU显示出抗脂原性活性,但没有影响脂解.
- 这些发现为进一步研究RCE及其对代谢调节的成分提供了基础.
关键词:
20 - 氧化cdysone 的使用情况.这种植物是Rhaponticum carthamoides (Willd.) 伊尔金. 伊尔金. 这就是伊尔金.脂肪细胞 (adipocytes) 是一种脂肪细胞.脂质生成 (adipogenesis) 是一种脂肪溶解 (adipolysis) 是一种增脂的过程.高性能薄层染色法 (HPTLC) 是一种高性能薄层染色法.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖波纳斯特龙A是一个A.土耳其氨酸 (turkesterone) 是一种更多相关视频
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