一种基于聚合物的指标,用于检测在草药中使用聚甲基甲酸盐 (PMMA) 检测甲沙
Rimadani Pratiwi1, Vandie Charlie1, Nyi Mekar Saptarini1
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjran, Bandung 45363, Indonesia.
Polymers
|July 14, 2023
概括
一个新的基于聚合物的指标可以快速检测在草药中被禁止的药物德克萨米他. 这种简单的测试为复杂的实验室分析提供了可靠的替代方案,以确保草药产品的安全性.
科学领域:
- 分析化学 分析化学
- 聚合物科学 聚合物科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 德甲经常被非法添加到草药中,因为它具有抗炎和缓解疼痛的特性.
- 在草药产品中不受控制地摄入德克萨米他,可能会导致严重的不良副作用.
- 目前在草本样本中检测德克萨米他的方法通常是复杂和耗时的.
研究的目的:
- 开发一种简单,快速,经济高效的基于聚合物的指标,用于在草药中检测甲基.
- 评估开发的指标条的选择性,灵敏性和稳定性.
- 通过使用现实世界草本样本验证指示条的性能.
主要方法:
- 指示条是通过将聚甲基甲烯酸 (PMMA) 聚合物与硫酸 (H2SO4) 混合制造的.
- 该方法涉及颜色测量反应,其中H2SO4与德克萨米他反应,产生鲜明的粉红紫色.
- 开发的指示条与各种草本样本进行了测试,结果与薄层染色学 (TLC) 和高性能液态染色学 (HPLC) 进行了比较.
主要成果:
- 基于聚合物的指标条带选择性地检测到德克萨米他,产生明显的颜色变化.
- 德克萨米他的检测极限被发现低至13.13 ppm.
- 指标条显示出高达36天的良好稳定性,并准确地识别了9个测试中的5个草本样本中的德甲,与TLC和HPLC结果一致.
结论:
- 开发的基于聚合物的指示条提供了一种简单,快速和适用的方法,用于在草药中现场检测甲基.
- 这一新型指标为质量控制和监管机构提供了一个有价值的工具,以确保草药产品的安全性.
- 这些发现突显了基于聚合物的指标在伪造传统药物的现场查方面的潜力.
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