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一项关于聚甲烯空心纤维膜的酸胆聚合物涂层的研究

Feihua Ye^1,2,3, Zhisheng Chen¹, Chunsheng Li^1,2

¹School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China.

|July 14, 2023

概括

一种新的胆聚合物涂层 (PMBT) 提高了聚甲基空腔纤维膜 (PMP-HFM) 的血液兼容性. 这种生物材料涂层抵抗溶解,减少血液凝固,增强膜氧化安全性.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
医疗器械涂层医疗器械涂层

背景情况:

聚甲基空腔纤维膜 (PMP-HFM) 在医疗器械中使用.
提高PMP-HFM的血液兼容性对于膜氧化等应用至关重要.
现有的涂层可能在稳定性和生物相容性方面存在局限性.

研究的目的:

为PMF-HFM开发和评估一种基于基胆的新型聚合物涂层 (PMBT).
评估PMBT涂层的PMP-HFM的物理化学特性和血液兼容性.
为了确定PMBT涂层在增强膜氧化的潜力.

主要方法:

通过自由基聚合来合成多 (MPC-co-BMA-co-TSMA) (PMBT).
在PMP-HFM表面上涂上PMBT的涂层.
使用ATR-FTIR,SEM,TGA,胀,接触角度和光测试进行表征.
通过全血接触和血小板粘附测试进行血红相容性评估.

主要成果:

统一的PMBT涂层由ATR-FTIR和SEM证实.
在35%的MPC单体中实现了最佳的PMBT稳定性.
优良的水友性质和耐乙醇和SDS溶解.
显著减少了血小板粘附和血液凝结.
证明了良好的血液兼容性.

结论:

PMBT聚合物可以成功地涂在PMP-HFM.上.
PMBT涂层增强了膜的水友性质和稳定性.
PMBT涂层显著改善了PMP-HFM的血液兼容性.
这种涂层有望改善膜氧化装置中的血液兼容性.

关键词:

空洞的纤维纤维膜膜.醇胆酸盐的使用方法聚合物聚合物的高分子.表面的修改表面的修改热分解热分解

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