通过超图的第三腹腔宽度与帕金森病的认知障碍有关
Hong-Ling Gao1, Yi Qu1, Sheng-Chong Chen2
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
CNS neuroscience & therapeutics
|July 14, 2023
概括
帕金森病 (PD) 患者的第三心室更宽,通过跨超声波 (TCS) 测量,预测认知能力下降. 这种成像标志物可以帮助识别患有认知障碍风险较高的PD患者.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年病的医生 老年病的医生
背景情况:
- 认知障碍影响了帕金森病 (PD) 患者的很大一部分.
- 确定可靠的神经成像标志物用于PD认知衰退仍然是一个挑战.
研究的目的:
- 为了研究第三腹腔宽度之间的关系,通过跨超声波 (TCS) 测量,和帕金森病 (PD) 的认知衰退.
主要方法:
- 174名PD患者接受了跨声学 (TCS) 测量第三室宽度.
- 认知功能被评估使用迷你精神状态检查 (MMSE).
- 采用接收器操作特征 (ROC) 和考克斯比例危险模型进行分析.
主要成果:
- 第三心室宽度与MMSE得分有负相关性.
- 确定了第三腹腔宽度的4.75毫米的最佳切线,用于查PD的认知障碍 (灵敏度62.7%,特异性75.6%).
- 第三心室宽度>4.75毫米的PD患者在21.5个月的中位随访期间,患有认知障碍的风险增加了7.975倍.
结论:
- 通过TCS评估的第三心室宽度是帕金森病中认知障碍发展的重要独立预测指标.
- 第三腹腔宽度的TCS测量为早期识别患有认知衰退风险的PD患者提供了潜在的工具.
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