循环RNAs作为双极性疾病潜在诊断生物标志物的新一类
Reza Asemi1, Amrollah Ebrahimi2, Michael R Hamblin3
1Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Current medicinal chemistry
|July 14, 2023
概括
循环RNAs (circRNAs) 与双相情感障碍 (BD) 的病理生理学有关. 通过液体活检分析circRNA资料可能为BD提供新的诊断和治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 是一种严重的情绪障碍,具有复杂和不确定的病因.
- 受遗传和表观遗传因素影响的基因表达失调是BD病理生理学的核心.
- 循环RNAs (circRNAs) 越来越多地被认为是它们在调节基因表达和神经元功能中的作用.
研究的目的:
- 审查目前对circRNAs参与双相情感障碍病理生理学的理解.
- 探索circRNAs作为BD诊断生物标志物的潜力.
- 讨论在BD中准circRNAs的治疗影响.
主要方法:
- 对调查精神疾病中circRNAs的研究进行文献综述,特别是BD.
- 分析现有证据,将circRNA与BD中受到影响的关键细胞过程 (如神经元活动和突触传播) 联系起来.
- 讨论在BD患者中使用液体活检进行circRNA分析的可行性.
主要成果:
- circRNAs在调节神经元活动,可塑性,突触传输和脱极化方面发挥着关键作用,这些过程与BD有关.
- 神经元细胞中改变的circRNA配置文件与BD的分子病理生理学有关.
- 通过液体活检进行circRNA分析为BD评估提供了一个有希望的,最少侵入性的方法.
结论:
- circRNAs是导致双相情感障碍的分子机制的重要贡献者.
- circRNA分析具有作为BD.新型诊断生物标记物的潜力.
- circRNAs代表了开发创新的BD治疗的新兴治疗点.
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