优化策略,以确定患2型糖尿病的高风险
Paula Andreghetto Bracco1,2, Maria Inês Schmidt1,3, Alvaro Vigo1,2
1Postgraduate Program in Epidemiology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
使用临床和实验室数据的新型糖尿病查方法比目前的策略更好. 这些改进的风险得分可以识别更多的高风险个体,同时减少虚假阳性,以更好地预防糖尿病.
科学领域:
- 内分泌学 在内分泌学.
- 预防医学 预防医学
- 生物统计学 生物统计学
背景情况:
- 有效的糖尿病预防依赖于高质量的查,以确定高风险的个体.
- 目前的查策略往往在平衡病例检测与被确定为高风险的人口比例方面面临局限性.
研究的目的:
- 将当前糖尿病查策略的诊断性能与基于得分的新规则进行比较.
- 通过使用增强的预测模型,识别患有2型糖尿病高风险的个体.
主要方法:
- 利用来自ELSA-巴西队列的数据,平均跟踪7.4年.
- 开发了合并社会经济,生活方式,临床和实验室变量后勤回归风险函数.
- 与传统的空腹血葡萄糖 (FPG),2小时血葡萄糖 (2hPG) 和糖化血红蛋白 (HbA1c) 截止值的预测能力的比较,使用和不使用查问卷.
主要成果:
- 禁食血葡萄糖 > 100 mg/dl 确定了 76.6% 的未来糖尿病病例,但标记了 40.6% 的样本为高风险.
- 使用美国糖尿病协会 (ADA) 问卷与FPG测试将标签减少到12.2%,但只确定了33%的病例.
- 基于使用连续临床和实验室变量的得分策略显示出更高的性能,在病例检测和错误阳性之间实现了更好的平衡.
结论:
- 目前的糖尿病查策略不如替代方法有效.
- 基于分数的风险函数利用连续的临床和实验室数据,为识别患糖尿病高风险的人提供更高的准确性.
更多相关视频
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Oral Hypoglycemic Agents: Biguanides and Glitazones
