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饮食和ADH7在七种哺乳动物阶级的演变
Swellan L Pinto1, Mareike C Janiak1,2, Gwen Dutyschaever1
1Department of Anthropology and Archaeology, University of Calgary, 2500 University Dr NW, Calgary, Alberta, Canada T2N 1N4.
Royal Society open science
|July 14, 2023
概括
对于代谢乙醇至关重要的ADH7基因在171种哺乳动物中表现出广泛的变异. 尽管有饮食联系,但复杂的因素,而不仅仅是饮食,似乎塑造了ADH7的进化和功能.
科学领域:
- 分子进化的分子进化.
- 进行比较的基因组学.
- 哺乳动物遗传学 哺乳动物遗传学
背景情况:
- 饮食变化影响基因进化,特别是营养代谢.
- 编码ADH4类酶的ADH7基因参与了来自含糖饮食 (水果,花蜜) 的乙醇代谢.
- 以前的研究表明,富含糖的饮食有利于ADH7突变和人类和其他哺乳动物的功能性保存.
研究的目的:
- 在大型哺乳动物数据集中调查ADH7基因序列变异.
- 分析ADH7.7的关键乙醇结合部位 (残留294) 的变化.
- 探索饮食行为对ADH7进化和功能的影响.
主要方法:
- 来自171种哺乳动物 (59种新测序) 的ADH7基因序列的比较分析.
- 检查294位点的氨基酸残留变异,对于ADH7-乙醇亲和力至关重要.
- 评估跨物种的ADH7基因保留和伪基因化.
主要成果:
- 观察到广泛的ADH7序列变异,特别是在果类和花类蝙蝠中,具有潜在的功能影响.
- 记录了ADH7基因保留和伪基因化的广泛变异.
- 很少有统计证据支持饮食行为对ADH7功能或哺乳动物中294位点的衍生基因的直接,总体影响.
结论:
- 哺乳动物的ADH7进化受简单的饮食关联之外的复杂因素的影响.
- 这项研究揭示了ADH7中显著的新遗传多样性,为未来的功能研究提供了途径.
- 了解ADH7进化有助于更广泛地了解由生态因素驱动的分子进化.
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