在患有早期双相情感障碍的患者中异常的动态功能网络连接
Ziyi Hu1, Chun Zhou1, Laichang He1
1Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, China.
Frontiers in psychiatry
|July 14, 2023
概括
早期出现的双相情感障碍 (BD) 显示了动态功能性大脑连接的改变,特别是在认知和感知网络中. 这些发现突显了dFNC的不稳定性,并为BD的神经生物学提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 早期出现的双相情感障碍 (BD) 是一种具有复杂神经生物学基础的严重心理健康状况.
- 了解早期BD中的动态功能大脑网络连接 (dFNC) 对于确定潜在的生物标志物和治疗点至关重要.
研究的目的:
- 与健康对照组 (HCs) 相比,研究早期BD患者的dFNC变化.
- 分析大脑网络的时间动态及其与早期发病性BD中的认知和感知功能之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 数据从39名早期发病的BD患者和22名HC患者获得.
- 独立组件分析 (ICA),滑动时间窗口和k-means集群被用来描述四个稳定的dFNC状态.
- 计算dFNC时间指标 (时间分数,平均停留时间,过渡次数) 并在各组之间进行比较.
主要成果:
- 在所有科目中,确定了四个不同的dFNC状态.
- 早期出现的BD患者在所有四个状态中都表现出明显改变的dFNC模式,主要影响认知和感知网络.
- 患有BD的患者在状态2的时间和停留时间缩短,在状态3的停留时间增加,与焦虑评分的相关性趋势.
结论:
- 患有早期BD的患者表现出异常的动态功能性大脑网络连接,其特点是认知和感知网络之间的不稳定性和受损协调.
- 这些发现为了解早期BD中情绪和认知缺陷的神经病理学提供了新的神经成像基础.
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