当代单克隆抗体在淋巴细胞疾病中的利用
Iyad Mansour1, Sangeetha Murugapandian1, Bekir Tanriover1
1Division of Nephrology, College of Medicine, The University of Arizona, Tucson.
Mayo Clinic proceedings. Innovations, quality & outcomes
|July 14, 2023
概括
治疗性单克隆抗体 (MAbs) 提供针对性治疗球细胞疾病,具有高特异性和低毒性. 这篇评论强调了它们在个性化医学和免疫介导疾病中的不断变化的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 治疗性单克隆抗体 (MAbs) 是一个快速扩大的药物类别,已被批准用于各种疾病,包括癌症,自身免疫性疾病和球细胞疾病.
- MAbs占每年FDA新药批准的20%,因其特异性,减少药物相互作用和低毒性而受到青,符合个性化医学原则.
研究的目的:
- 为了提供一个全面的分类学,药理学和单克隆抗体在球细胞疾病治疗应用的综合概述.
- 审查最近的进展和目前的证据基础,用于MAb在治疗免疫介导的质细胞疾病的利用.
主要方法:
- 在PubMed上使用关键词进行文献搜索:单克隆抗体,质细胞疾病,药理动力学,药理动力学,免疫球蛋白,小鼠,奇米,人性化和完全人类.
- 搜索仅限于2018年至2023年间发表的同行评审文章,优先考虑基于证据的审查随机对照试验.
主要成果:
- 单克隆抗体显著推进了针对性治疗免疫介导的球细胞疾病.
- 目前正在进行的多项随机对照试验表明,在病学中,对基于MAb的疗法进行范式转变.
结论:
- 单克隆抗体在现代治疗质细胞疾病中至关重要,提供个性化医疗方法.
- 进一步的研究和认可对于扩大MAbs在实验环境和这些疾病的临床实践中的使用至关重要.
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