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Updated: Jul 23, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

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波形连贯相位分析解码了Ras GTPase超级家族的通用切换机制

Zenia Motiwala1,2, Anand S Sandholu1,2, Durba Sengupta2,3

  • 1Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune 411008, India.

iScience
|July 14, 2023
PubMed
概括

研究人员开发了一种新的波形连贯相合 (WPC) 分析,以定义Ras GTPase的功能状态. 该方法揭示了切换区域的结构变化如何决定蛋白质功能,并确定了瘤性GTPases中的异常机制.

关键词:
生物分子是生物分子.蛋白质结构方面 蛋白质结构方面结构生物学是结构生物学.

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