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Updated: Jul 23, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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一种用于多克隆抗原特异性T细胞向基因组编辑 (TarGET) 的方法,用于收养细胞转移应用

Darya Palianina1, Raphaël B Di Roberto2, Rocío Castellanos-Rueda2,3

  • 1Department of Biomedicine, University and University Hospital of Basel, 4056 Basel, Switzerland.

Molecular therapy. Methods & clinical development
|July 14, 2023
PubMed
概括

我们开发了一种基于CRISPR的方法,在采用细胞疗法后编码和跟踪病毒特异性T细胞. 这种方法可以精确监测T细胞扩张和基因表达,从而改善免疫治疗策略.

关键词:
克里斯普尔-Cas9是什么意思这是EBV的EBV.通过T细胞治疗治疗.TCR 测序的测序方法细胞毒性T细胞的发生.深度测序是一种深度测序.基因组编辑 基因组编辑谱系追踪 谱系追踪 谱系追踪这就是scRNA-seqq.病毒特异性的T细胞.

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