在健康和患者社区之间,甲素耐药黄金葡萄球菌的高交叉传播率
Behnood Haji Sheikhzadeh1, Leila Rahbarnia2, Alireza Dehnad3
1Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Iranian journal of microbiology
|July 14, 2023
概括
与健康人群相比,甲素耐药黄金葡萄球菌 (MRSA) 较为普遍,在血液透析患者中具有明显的毒性因子. 这凸显了针对脆弱患者群体的有针对性的监测和感染控制策略的需要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 甲素耐药黄金葡萄球菌 (MRSA) 构成重大威胁,在医疗保健机构造成高死亡率和发病率.
- 了解MRSA的遗传和病毒性概况对于有效的治疗和控制至关重要.
研究的目的:
- 调查MRSA的毒性因子,分子类型和抗生素耐药性模式的流行情况.
- 为了比较来自血液透析患者和健康社区的MRSA分离物之间的这些特征.
主要方法:
- 从231名血液透析患者和400名健康个体收集了鼻腔样本.
- 用聚合酶连锁反应 (PCR) 来识别毒性因素.
- 肠杆菌重复性基因间共识 (ERIC-PCR) 被用于分子类型.
主要成果:
- 在血液透析患者中检测到的黄金色细菌分离物的47.56%中检测到MRSA,而在健康社区中为36.66%.
- 关键的毒性因子,如pvl和tsst-1,在患者隔离组中明显更频繁.
- 埃里克PCR发现了7个群,两组的分离物混合在一起,这表明社区和患者菌株具有遗传相似性.
结论:
- 在血液透析患者和一般社区的MRSA之间,毒性因子频率存在显著差异.
- 血液透析患者携带具有潜在更高毒性的MRSA菌株.
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