在COVID-19疫苗接种后,与中风相关的因素:全州范围的分析
Fadi Nahab1, Rana Bayakly2, Mary Elizabeth Sexton3
1Departments of Neurology & Pediatrics, Emory University, Atlanta, GA, United States.
Frontiers in neurology
|July 14, 2023
概括
在接种疫苗后,COVID-19感染显著增加了中风风险. 与BNT162b2相比,Ad26.COV2.S疫苗显示出缺血性中风的风险更高,而mRNA-1273没有差异.
科学领域:
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
- 神经学 神经学
背景情况:
- 评估COVID-19疫苗接种,COVID-19感染和中风风险之间的关联.
- 根据COVID-19疫苗类型,调查中风风险的潜在差异.
研究的目的:
- 评估疫苗类型,COVID-19感染和COVID-19疫苗接种后不久的中风风险之间的关联.
- 为了比较不同类型的COVID-19疫苗接种者的中风相对风险.
主要方法:
- 回顾性队列研究分析了格鲁吉亚免疫和中风登记处的数据.
- 约500万成年接种疫苗的免疫接种,需要报告的疾病和急性中风监测数据.
- 根据疫苗类型 (BNT162b2,mRNA-1273,Ad26.COV2.S) 估计21天疫苗接种后的中风发生率和相对风险.
主要成果:
- 接种疫苗后21天内同时感染COVID-19会增加缺血性中风风险 (OR=8.00) 和出血性中风风险 (OR=5.23).
- 与BNT162b2 (OR=1.57) 相比,Ad26.COV2.S疫苗与21天内缺血性中风风险增加57%有关.
- 在mRNA-1273和BNT162b2接受者之间没有观察到中风风险的显著差异.
结论:
- 同时的COVID-19感染与疫苗接种后的早期缺血性和出血性中风密切相关.
- 与BNT162b2.2.相比,Ad26.COV2.S疫苗显示早期疫苗接种后缺血性中风的风险更高.
- 需要进一步的研究来考虑并发症作为潜在的中风决定因素.
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