在多囊性卵巢综合征中,颗粒细胞的氧化应激和线粒体功能障碍在多囊性卵巢综合征中
Yiyin Gao1, Yinggang Zou1, Guijie Wu1
1Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Frontiers in medicine
|July 14, 2023
概括
多囊性卵巢综合征 (PCOS) 涉及排卵障碍和不孕症. 氧化应激和颗粒细胞中的线粒体功能障碍有助于PCOS的发展和卵巢功能受损.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 细胞生物学 细胞生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 多囊卵巢综合征 (PCOS) 影响全球5-15%的生育年龄妇女,导致无排卵不育.
- PCOS表现为排卵障碍,缺血症,皮症和肥胖症,并与糖尿病和心血管疾病等严重并发症有关.
- 氧化应激 (OS) 是PCOS病因的一个关键因素,线粒体是活性氧物种 (ROS) 的主要来源.
研究的目的:
- 审查证据,将粒状细胞 (GCs) 中的氧化应激和线粒体功能障碍与PCOS中的卵巢功能受损联系起来.
- 探索GCs在卵泡发育中的作用及其功能障碍如何导致PCOS症状.
- 总结PCOS GCs中OS标志物升高和线粒体功能异常的发现.
主要方法:
- 对调查PCOS中氧化应激标志物的研究进行文献综述.
- 分析PCOS患者颗粒细胞中线粒体功能的研究.
- 综合关于GC功能障碍和PCOS病原体之间的关系的发现.
主要成果:
- 与健康个体相比,患有PCOS的患者在GC中表现出明显更高水平的OS标志物.
- 在GC中线粒体功能在患有PCOS的女性中明显异常.
- 在GC中这些细胞功能障碍与卵巢功能受损和PCOS进展相关.
结论:
- 颗粒细胞中的氧化应激和线粒体功能障碍与PCOS的发展和进展密切相关.
- GC功能障碍直接影响毛囊发育,有助于PCOS的临床表现.
- 针对GC中的OS和线粒体通路可能为PCOS相关的不孕症提供治疗策略.
相关概念视频
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Hormonal Control of the Ovarian Cycle
585
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
585
Folliculogenesis
872
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
872
Electron Transport Chain: Complex I and II
14.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.5K
Ovarian Cycle
1.4K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.4K
Peroxisomes
13.6K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
13.6K


