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植物产的假定小鼠特异性避孕的免疫性和避孕疗效

Khadijeh Ghasemian¹, Inge Broer¹, Jennifer Schön²

¹Department of Agrobiotechnology and Risk Assessment for Bio and Gene Technology, Faculty of Agricultural and Environmental Sciences, University of Rostock, Rostock, Germany.

Frontiers in plant science

|July 14, 2023

概括

针对小鼠卵细胞和精子的植物制造的避孕具有免疫性,并减少了39%的 litter 规模. 这表明了开发新型小鼠种群控制疫苗的可行策略.

科学领域:

生殖生物学生殖生物学
植物生物技术植物生物技术
疫苗的研发工作正在进行中.

背景情况:

动物种群控制需要特定物种的避孕疫苗.
开发有效的避孕疫苗需要识别和生产抗原.

研究的目的:

在植物中生产特定于小鼠的避孕 (mZP2和mIzumo1).
为了评估植物产生的抗原在小鼠中的免疫性和避孕疗效.

主要方法:

在尼科蒂亚娜本塔米亚纳中经由农细菌介导的短暂表达产生mZP2和mIzumo1.
用植物产的抗原对雌性BALB/c小鼠进行皮下免疫接种.
免疫反应的评估, litter 尺寸的减少,以及抗体与卵细胞的结合.

主要成果:

在植物中成功产生mZP2-3和mIzumo1-3抗原.
用植物性抗原免疫的小鼠获得了系统性免疫反应.
在接受治疗的小鼠中,观察到平均 litter 尺寸减少了 39%,与抗体水平相关.
诱导的抗体与小鼠卵细胞结合.

结论:

植物可以被用来生产具有成本效益的避孕.
植物产生的避孕抗原在降低小鼠生育能力方面表现出有效性.
这种方法为开发用于动物种群管理的口服避孕疫苗提供了一个有希望的途径.

关键词:

这就是伊兹莫莫的意义.尼科蒂亚纳 (Nicotiana benthamiana) 是一种植物.这里就是Zona pellucida.这是一种避孕疫苗.植物分子农业植物分子农业

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