肠道微生物群和在慢性病中纠正它的方法
Nikolay V Sturov1, Sergey V Popov1, Igor I Belikov1
1Peoples' Friendship University of Russia (RUDN University), Department of General Practice, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.
Indian journal of nephrology
|July 14, 2023
概括
慢性病 (CKD) 影响了13%的俄罗斯人. 本综述探讨了肠道微生物群如何影响CKD进展,并讨论了对透析前患者的潜在干预措施.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 俄罗斯慢性病 (CKD) 的高患病率需要新的治疗策略.
- 人们越来越认识到肠道微生物群在CKD进展中的作用.
- 目前对晚期CKD的治疗方法复杂且昂贵,这凸显了对透析前干预的需要.
研究的目的:
- 审查当前对健康个体和慢性结核病患者肠道微生物群组成的理解.
- 阐明肠-轴内的相互作用机制.
- 讨论CKD肠道微生物群的失调及其纠正的潜在策略.
主要方法:
- 关于肠道微生物群和CKD的最近研究的文献综述.
- 对微生物群组成和功能数据的分析.
- 在肠-轴上综合信息.
主要成果:
- 与健康个体相比,在CKD患者中观察到肠道微生物群组成的显著变化.
- 肠道微生物群通过各种机制影响CKD的进展,包括产生尿素毒素.
- 肠道失生症的特定模式与CKD的不同阶段有关.
结论:
- 肠道微生物群在CKD的发病和进展中起着至关重要的作用.
- 准肠道微生物群为在透析前的CKD管理中新的治疗方法提供了一个有希望的途径.
- 需要进一步的研究,以充分理解和利用肠道微生物群调节在CKD中的治疗潜力.
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