使用PROPKD得分预测印度ADPKD队列中进展风险 - 一个单一中心的回顾性研究
Shivendra Singh1, H C Sreenidhi1, Parimal Das2
1Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Indian journal of nephrology
|July 14, 2023
概括
该PROPKD得分有效地预测了自体主导多囊性病 (ADPKD) 的快速进展. 根据PROPKD得分或临床因素识别的高风险ADPKD患者经历了早期末期病 (ESRD).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 是一个遗传学.
- 医学研究 医学研究
背景情况:
- 自体主导多囊性病 (ADPKD) 呈现出可变的基因型-表现型表达.
- 鉴定ADPKD快速进展的预测因新的向疗法而至关重要.
- PROPKD评分结合了遗传和临床因素来评估进展风险.
研究的目的:
- 为了评估印度患者使用PROPKD得分的ADPKD进展风险.
- 确定基于PROPKD评分的风险组与早期末期病 (ESRD) 之间的关联.
- 评估临床变量和基因突变对ADPKD进展的预测价值.
主要方法:
- 从2006年到2021年对ADPKD患者进行ESRD的回顾性研究.
- 基于性别,高血压发作,泌尿病事件和PKD1/PKD2突变的PROPKD得分计算.
- 使用临床变量和完整的PROPKD得分将风险分类为低,中等和高风险组.
主要成果:
- 这项研究包括73名ADPKD患者,ESRD的中位年龄为54岁.
- 基于临床变量 (HR 4.570) 和PROPKD评分 (HR 6.594) 的高风险组与早期ESRD有显著的关联.
- 临床变量P值<0.001和P=0.003的PROPKD得分表示统计学意义.
结论:
- 高风险的ADPKD患者,根据PROPKD得分来确定,面临着早期进展到ESRD的风险增加.
- 仅仅临床变量,当用于风险分层时,也表明与加速疾病进展的显著关联.
- PROPKD得分是预测印度人口ADPKD进展的宝贵工具.
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