尿液TNF-α作为慢性原发性腰部疼痛的潜在生物标志物
Carlos Gevers-Montoro1,2,3, Mariana Puente-Tobares1, Aléxiane Monréal1
1Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.
Frontiers in integrative neuroscience
|July 14, 2023
概括
尿路瘤亡因子-α (TNF-α) 水平升高可能预测慢性腰痛 (CLBP) 的结果. 较高的TNF-α基线和治疗后的变化与CLBP患者的疼痛和残疾改善相关.
科学领域:
- 生物化学 生化学
- 免疫学 免疫学 免疫学
- 疼痛医学 医学 疼痛医学
背景情况:
- 超过三分之二的腰部疼痛患者经历了长期的症状.
- 预测慢性腰部疼痛 (CPLBP) 的发展和恢复仍然具有挑战性.
- 瘤亡因子-α (TNF-α) 的升高与LBP恢复不良和nociplastic疼痛机制有关.
研究的目的:
- 探索尿液TNF-α作为CPLBP结果的预测因素.
- 通过尿液TNF-α来表征CPLBP的临床特征.
- 评估脊柱操纵疗法 (SMT) 期间的TNF-α变化.
主要方法:
- 招募了24名CPLBP患者和24名对照.
- 在基线和SMT4周后测量尿TNF-α.
- 基于疼痛轨迹和治疗反应的TNF-α水平的比较.
主要成果:
- 与对照组相比,CPLBP患者的尿TNF-α基线较高.
- 持久性疼痛患者的TNF-α比偶发性CPLBP患者高.
- 基线和SMT后TNF-α水平预测了疼痛和残疾的变化.
结论:
- 尿液TNF-α显示出作为CPLBP的预后生物标志物的潜力.
- 需要进一步的研究来验证尿液TNF-α的临床用途.
- TNF-α可能在CPLBP病原和治疗反应中发挥作用.
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