调节细胞死亡和瘤治疗中的瘤相关巨细胞的双重身份
Yingying Shao1,2, Yu Wang1,2, Ranran Su1,2
1Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Heliyon
|July 14, 2023
概括
与瘤相关的巨细胞 (TAMs) 促进瘤生长和免疫抑制. 针对TAM及其与编程死亡途径的相互作用对于提高癌症免疫疗法和治疗疗效至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 瘤相关巨细胞 (TAMs) 显著影响瘤微环境 (TME) 和瘤细胞行为.
- 在癌症发育过程中,TAMs表现出不同的功能特征,在癌症发育过程中充当瘤促进剂和免疫抑制剂.
- 在TAM亚群中的动态变化对于塑造TME和影响疾病进展至关重要.
研究的目的:
- 探索TAMs,编程死亡途径和瘤治疗之间的复杂相互作用.
- 阐明TAMs影响瘤细胞增殖,迁移和遗传不稳定的机制.
- 确定调节TAM两极化的策略,以增强抗瘤免疫力和提高免疫疗法的疗效.
主要方法:
- 本综述综合了有关TAM生物学及其在癌症中的作用的当前研究.
- 它分析了TAM两极分化的机制及其对TME的影响.
- 该审查整合了有关TAM与编程死亡配体的相互作用及其对癌症治疗的影响的发现.
主要成果:
- TAMs是TME的关键调节者,影响瘤进展和免疫逃避.
- 改变TAM极化对于重塑免疫抑制和促进抗瘤免疫反应至关重要.
- 了解TAM机制对于优化当前免疫疗法和开发新型癌症治疗至关重要.
结论:
- 由于它们在瘤发育中的多方面的作用,TAMs是癌症治疗的关键目标.
- 调节TAM是一种有前途的策略,可以提高现有癌症治疗的有效性,特别是免疫疗法.
- 需要对TAMs,编程死亡和瘤治疗的三元相互作用进行进一步的研究,以充分利用其治疗潜力.
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