从免疫生物学到病态诊断的口腔慢性移植对宿主疾病的观点
Victor Tollemar1, Karin Garming Legert1, Rachael V Sugars1
1Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Frontiers in immunology
|July 14, 2023
概括
慢性移植与宿主疾病 (cGVHD) 在血液细胞移植 (HCT) 后经常影响口腔. 了解口腔cGVHD的理解
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 慢性移植对宿主疾病 (cGVHD) 是血造细胞移植 (HCT) 后的一种严重并发症.
- 口服cGVHD是常见的 (45-83%),通常作为早期指标呈现状小虫病变和病变症状.
- 目前口腔cGVHD的诊断标准缺乏特异性,并且难以捕捉整个疾病谱.
研究的目的:
- 审查有关口服cGVHD病理生理学和生物阶段的当前知识.
- 解决口腔cGVHD的诊断挑战和知识差距.
- 改善口腔cGVHD的临床管理和研究质量.
主要方法:
- 文献综述侧重于口服cGVHD的病理生理学和生物阶段.
- 在疾病进展中分析免疫反应,包括T细胞和巨细胞.
- 讨论诊断标准和治疗策略的考虑.
主要成果:
- 口腔cGVHD涉及不同的病理生理阶段:急性炎症,慢性炎症/免疫失调以及纤维化愈合.
- 免疫反应驱动这些阶段,可能导致恶性转变.
- 患者特定的疾病进展需要个性化诊断和管理方法.
结论:
- 对口腔cGVHD病理生理学的更深入的理解对于改善患者的治疗结果至关重要.
- 解决知识差距将提高临床管理和研究质量.
- 有效的口腔cGVHD护理需要个性化的诊断和治疗策略.
关键词:
诊断标准 诊断标准 诊断标准 诊断标准有病态形式的病态形式.口腔慢性移植对宿主疾病在口服中使用的液化物.在口腔的粘膜.口服潜在的恶性疾病.病理生理学 病理生理学西卡综合征是什么?西卡综合征是什么更多相关视频
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