原发性甲状腺功能过高和甲状腺切除术对功能的长期影响
Catherine Y Zhu1, Hui X Zhou2,3, Chi-Hong Tseng4
1Section of Endocrine Surgery, Department of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, United States.
European journal of endocrinology
|July 14, 2023
概括
在原发性副甲状腺症 (PHPT) 中,加快功能下降 (eGFR) 与高水平发生. 副甲状腺切除术可以减轻受影响患者的这种下降.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术研究的研究.
背景情况:
- 初级甲状腺功能障碍症 (PHPT) 是一种关于功能障碍作为甲状腺切除术指示的有限证据的疾病.
- 在PHPT中,了解功能自然史至关重要.
研究的目的:
- 为了研究PHPT患者功能进展.
- 为了确定副甲状腺切除术是否会影响PHPT患者的结局.
主要方法:
- 一项匹配对照研究,涉及6058名PHPT受试者和16388名对照者,从2000年至2016年.
- 分析了10年间估计的淋巴透率 (eGFR) 轨迹,按高血症的严重程度分层.
- 间断时间序列分析,比较PHPT患者的eGFR,有和没有副甲状腺切除术.
主要成果:
- 在PHPT患者中观察到加速的eGFR下降,血清>2.87 mmol/L (11.5 mg/dL),影响了16%的病例.
- 与对照组相比,这些患者的eGFR下降率明显高于对照组.
- 副甲状腺切除术减轻了血清>2.87 mmol/L的患者的EGFR下降.
结论:
- 少数PHPT患者血清水平升高 (>2.87 mmol/L) 经历了功能加速下降.
- 副甲状腺切除术在减轻这种衰退方面显示出潜在的益处,这表明在管理这些患者的结局时应考虑它.
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