颗粒物2.5 (PM2.5),PM2.5吸收率和COVID-19风险之间的因果关系:一个两样本的门德尔随机化研究
Chenxi Liu1,2, Jia Peng1,2, Yubo Liu1,2
1Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Journal of global health
|July 14, 2023
概括
颗粒物吸收,而不是PM2.5本身,显示了与COVID-19感染,住院和严重症状的因果关系. 减少空气污染可能有助于减轻COVID-19的风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 观察性研究表明,颗粒物 (PM2.5) 和COVID-19之间存在联系.
- 之前的研究没有利用孟德尔随机化 (MR) 来确定因果关系.
- 因果推断对于理解PM2.5-COVID-19关系至关重要.
研究的目的:
- 调查PM2.5吸收率与COVID-19风险之间的潜在因果关系.
- 使用MR检查PM2.5暴露和COVID-19结果之间的关系.
主要方法:
- 利用两样MR分析与来自英国生物银行和IEU开放GWAS项目的全基因组关联研究 (GWAS) 数据.
- 采用逆方差加权 (IVW) 方法作为主要分析.
- 应用了补充的MR方法,包括MR Egger,加权中位数和MR-PRESSO以获得强度.
主要成果:
- 吸收PM2.5与增加的COVID-19感染 (OR=2.64),住院 (OR=3.52) 和严重的呼吸道症状 (OR=28.74) 有因果关系.
- 在PM2.5水平和COVID-19之间没有发现显著的因果关系.
- 在各种敏感性分析中,结果一致.
结论:
- 吸收PM2.5可能是COVID-19感染,住院和严重症状的潜在因果风险因素.
- 空气污染控制策略可能在管理和预防严重的COVID-19中发挥作用.
- 对MR的分析证实了空气污染成分与呼吸道传染病之间的因果关系.
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