骨矿物质密度是否是经更年期妇女患有光线A乳腺癌的预后因素?
Seungju Lee1, Hyun Yul Kim1, Youn Joo Jung1
1Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Korean journal of clinical oncology
|July 14, 2023
概括
骨矿物质密度 (BMD) 似乎不是乳腺癌复发或转移的重要风险因素,在经更年期的女性与光线A乳腺癌. 这项研究发现,骨质量水平或变化与无疾病生存率之间没有显著的关联.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 骨矿物质密度 (BMD) 是一个已知的因素,影响绝经后妇女的健康.
- 之前的研究表明,骨质疏松症与乳腺癌风险之间存在有争议的关联.
- 乳腺癌 Luminal A 是绝经后妇女常见的亚型.
研究的目的:
- 为了研究骨矿物质密度 (BMD) 与乳腺癌复发,转移或逆侧癌症的风险之间的关联,在患有光线A乳腺癌的绝经后患者中.
- 为了澄清BMD和乳腺癌结局之间的有争议的关系.
主要方法:
- 追溯分析了348名在2012年至2016年期间接受治疗的患有光线A乳腺癌的绝经后患者.
- 患者按手术前的骨髓质量 (正常与低) 和骨髓质量变化 (没有变化,改善,恶化) 分类.
- 事件定义为复发,逆侧乳腺癌或远程转移;中位数随访时间为78个月.
主要成果:
- 129名患者的BMD正常,219名患者的BMD低 (骨质疏松症或骨质疏松症).
- 只有14名患者 (4.0%) 经历了不良事件 (复发,转移,逆侧癌症).
- 在正常BMD (95.0%) 和低BMD (98.2%) 组 (P=0.33),以及在BMD变化组 (P=0.79) 之间,五年无疾病生存率相似.
结论:
- 骨矿物质密度 (BMD) 在这个队列中没有被发现是复发,转移或逆侧乳腺癌的统计学上显著预测因素.
- 这些发现表明,骨质量可能不是绝经后妇女光线A乳腺癌结局的关键风险因素.
- 可能需要进一步的研究,以充分阐明骨健康和乳腺癌预后之间的复杂相互作用.
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