2型糖尿病患者的心血管自主神经病变,有或没有感官运动性多神经病变
Emil Peters1, Mustapha Itani2, Alexander G Kristensen1,3
1Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Journal of the peripheral nervous system : JPNS
|July 14, 2023
概括
心血管自主神经病变 (CAN) 是常见的2型糖尿病患者与远端感觉运动多神经病变 (DPN). 自主症状与CAN和DPN有关,但对于诊断来说还不够具体.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病患者的心血管自主神经病变 (CAN) 与不良结果有关.
- 远端感觉运动性多神经病变 (DPN) 是2型糖尿病的常见并发症.
- 了解DPN和CAN之间的相互作用对于管理糖尿病并发症至关重要.
研究的目的:
- 评估2型糖尿病患者的CAN症状和自主症状.
- 调查DPN对CAN的患病率和特征的影响.
- 为了确定患有癌症的患者的特征.
主要方法:
- 分析了374名2型糖尿病患者和DD2队列的健康对照.
- 使用VagusTM设备进行的心血管自主反射测试,诊断出CAN.
- 自主症状使用COMPASS 31问卷进行了评估;DPN是根据多伦多的共识标准定义的.
主要成果:
- 确定的CAN在22%的DPN患者,7%的DPN患者和3%的对照患者中被发现.
- 91%的确定的CAN患者也患有DPN.
- 患有DPN和CAN的患者报告了显著更高的自主症状得分.
结论:
- 五分之一的DPN患者表现出CAN,突出显著的关联.
- 虽然自主症状与DPN和CAN相关,但它们缺乏CAN诊断的特异性.
- 糖尿病中的CAN与HbA1c和年龄有关,这表明这些是潜在的危险因素.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
17
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
Disorders of the Autonomic Nervous System
711
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
711
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Peripheral Artery Disease IV: Nursing Management
12
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
12


