对抑郁和焦虑障碍的跨诊断性认知行为治疗统一方案的有效性:一个随机对照试验
Masaya Ito1, Masaru Horikoshi1, Noriko Kato1,2
1National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
Psychological medicine
|July 14, 2023
概括
统一协议 (UP) 有效地减少患有抑郁和/或焦虑障碍的患者的抑郁和焦虑症状. 这种跨诊断治疗在43周内表现出持续改善,证明了其有效性.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 心理治疗研究 心理治疗研究
背景情况:
- 统一协议 (UP) 对情绪障碍的跨诊断治疗的有效性在患有抑郁症的患者中还没有得到充分的研究.
- 这项研究调查了UP在改善抑郁症和/或焦虑症患者抑郁症症状方面的有效性.
研究的目的:
- 评估统一方案 (UP) 与通常治疗 (TAU) 相比在减少抑郁症状方面的有效性.
- 评估UP对焦虑症状,临床总体印象和抑郁和/或焦虑障碍患者的缓解率的影响.
主要方法:
- 一个评估者盲目的,随机的,为期20周的平行组优势试验,将UP与TAU (UP-TAU) 与TAU (WL-TAU) 的等待列表进行比较.
- 包括被诊断患有抑郁和/或焦虑障碍并具有抑郁症状的参与者 (N=104).
- 主要结局是21周以GRID-Hamilton抑郁症评级尺度 (GRID-HAMD) 测量的抑郁症状.
主要成果:
- 与WL-TAU相比,UP-TAU组显示了抑郁症状的显著减少 (平均变化差 = -3.99).
- UP-TAU在减少焦虑症状和改善临床总体印象方面表现出优越性.
- 在UP-TAU组观察到的改善在43周后得到维持,没有报告严重不良事件.
结论:
- 统一协议 (UP) 是诊断为抑郁症和/或焦虑症患者的有效治疗方法.
- UP为管理复杂情绪障碍提供了可行的治疗选择,显示了持续的益处.
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