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Updated: Jul 23, 2025

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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结合癌位缺氧诱导因子2α与prolyl氧酶域2的结构基础

William D Figg1, Giorgia Fiorini1, Rasheduzzaman Chowdhury1

  • 1Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford, Institute for Antimicrobial Research, University of Oxford, Oxford, UK.

Proteins
|July 14, 2023
PubMed
概括

低氧诱导因子基酶 (PHDs) 调节HIFα降解. 结构研究揭示了PHD2结合模式,为贫血,红细胞瘤和清细胞癌 (ccRCC) 提供了新的治疗方法.

关键词:
贝尔祖提芬是其中的一个.特里科普拉克斯附着体和Pseudomonas putida的prolyl氧化酶域 (TaPHD和PPHD) 进行了检测.清细胞细胞癌是什么?红色素质的人类形成.缺氧诱导因子异型2-α (HIF2α或EPAS1)甲基基酶域 (PHD或EGLN) 是一个α-格酸盐/2-格酸盐氧化酶

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