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经过不同延迟时间后,在针对性肌肉再内尔化后恢复神经功能

Yuanheng Li¹, Jiangping Huang¹, Yuling Chen²

¹Key Laboratory of Human-Machine Intelligence-Synergy Systems and Branch of Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China.

Neural regeneration research

|July 14, 2023

概括

延迟向肌肉再生 (TMR) 有效地恢复了老鼠的神经功能,即使在神经损伤后长达4周后进行. 这一发现支持TMR作为截肢者可行的选择,无论手术时间如何.

科学领域:

再生医学是一种再生医学.
神经科学是一个神经科学.
手术创新在外科创新.

背景情况:

向肌肉再生 (TMR) 是一种用于改善截肢者的假肢控制的手术程序.
延迟TMR对神经损伤后功能恢复的影响尚不清楚.

研究的目的:

在大鼠模型中研究延迟TMR对神经肌肉功能恢复的影响.
为了确定延迟TMR是否会影响神经切割后功能恢复的程度.

主要方法:

在老鼠前肢中,中部和肌皮神经被切断.
靠近的中枢神经干与远部肌皮神经干连接,间隔即时,2周和4周.
记录和分析了来自重新内核化的双臂肌肉内肌电信号.

主要成果:

肌电信号幅度在双臂肌肉中随着时间的推移逐渐增加TMR后.
在肌电信号,肌肉纤维形态或不同TMR延迟周期的老鼠的理行为中没有观察到显著差异.
推迟四周的TMR实现了与即时TMR相比的功能恢复.

结论:

延迟TMR,即使在神经损伤后长达4周,也可以有效地恢复神经肌肉功能.
在这种大鼠模型中,TMR的时间不会显著影响功能恢复的程度.
这些发现表明,在截肢患者的临床应用中,TMR的手术时间灵活.

关键词:

双臂臂 (BRACHAI) 双臂 (BRACHAI) 是一个双臂.延迟神经修复的时间.延迟的向性肌肉重新内核化功能性的重建重建.理试验理试验植入了植入的电极.肌肉内肌电信号肌肉内肌电信号中间神经的中间神经.运动功能运动功能运动功能神经转移神经转移神经转移神经转移

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