通过通过小RNA介导的NLR表达的控制来调节植物免疫
Diego López-Márquez1, Ángel Del-Espino2, Javier Ruiz-Albert2
1Department of Biology, University of Copenhagen, Copenhagen N, DK-2200, Denmark.
Journal of experimental botany
|July 14, 2023
概括
植物使用小RNA,包括22nt小RNA,来调节核酸结合的氨酸丰富重复蛋白 (NLR). 这种精确的控制可以增强植物对病原体的免疫力,同时防止有害的自身免疫力.
科学领域:
- 植物免疫力 植物免疫力
- 分子生物学分子生物学
- 基因调节 基因调节
背景情况:
- 植物具有用于模式触发免疫 (PTI) 的模式识别受体 (PRR) 和用于效应器触发免疫 (ETI) 的核酸结合氨酸丰富的重复蛋白 (NLR).
- 对NLR水平的调节失调可能导致自身免疫,影响植物的生存.
- 小RNA介导的基因调节对于控制NLR剂量至关重要.
研究的目的:
- 总结关于NLR基因调节中的微RNA (miRNA) 和小干扰RNA (siRNA) 的当前知识.
- 为了突出22nt miRNAs在NLR剂量控制中的特定作用.
- 提出小RNA通路如何连接PTI和NLR防御,以提高植物的响应能力.
主要方法:
- 对植物免疫,PRR,NLR和小RNA通路的现有文献的审查.
- 分析22nt小RNA调节NLR表达的机制.
- 综合连接 PTI,ETI 和小RNA介导的 NLR 控制的信息.
主要成果:
- 22nt miRNAs是NLR基因表达的关键调节者,增强了对主要标的抑制.
- 这些miRNAs还诱导二次小干扰RNAs (siRNAs),导致更广泛的NLR抑制.
- 较高的NLR水平是有害的,小RNA对于维持适当的NLR剂量至关重要.
结论:
- 微RNA和小干扰RNA通路提供了PTI和NLR介导防御之间的关键联系.
- 这种调节允许植物微调免疫反应,增加病原体防御和预防自身免疫.
- 小RNA对NLRs的调节对于强大而适应的植物免疫力至关重要.
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